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KMID : 0359319940340030601
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Korean Journal of Veterinary Research
1994 Volume.34 No. 3 p.601 ~ p.607
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Fetal growth retardation induced by maternal exposure to phenol in the rat
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Abstract
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This study was carried out to investigate the potential of phenol to induce embryotoxicity in the Sprague-Dawley rat. Seventy mated rats were distributed among three treated troups, a vehicle control group and a negative control group. Phenol was at dose levels of 20, 60 and 180㎎/㎏/day adminsistered by gavage to pregnant rats three times per day from days 7 to 12 of gestation. All dams were subjected to the caesarean section on day 20 of gestation. At 120㎎/㎏, dams exhibited decreased locomotivity. In addition, both weight reduction and retarded ossification of fetuses were observed. There were no signs of maternal toxicity or embryotoxicity at 20 and 60㎎/㎏.
The results show that phenol induces fetal growth retardation at maternally subtoxic dose in rats.
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